The Sisters In Spirit initiative is a research, education and policy initiative funded by Status of Women Canada. The initiative is designed to address the disturbing numbers of missing and murdered Aboriginal women and girls in Canada. This report to Families and Communities summarizes information gained through interviews with participating families about their missing or murdered loved ones, as well as demographic and statistical research. The interviews use a story telling methodology based on a life cycle approach to share the life stories of these Aboriginal women and girls. Policy recommendations and future directions for investigation are summarised.